Czasopismo | CHEMIK | Rocznik 2024 - zeszyt 1

Potencjał wykorzystania metabolomiki w badaniach przemysłowych

Potential of using metabolomics in industrial research

10.15199/5.2024.1.3

nr katalogowy: 148526
10.15199/5.2024.1.3

Streszczenie

Metabolomika, należąca do nauk omicznych, jest podejściem analitycznym służącym do określania zmian jakościowych i ilościowych w składzie próbki (metabolomu) przy pomocy zaawansowanych metod analitycznych, takich jak spektroskopia magnetycznego rezonansu jądrowego (NMR) oraz spektrometria mas (MS) sprzężona z technikami separacyjnymi (np. LC-MS, GC-MS, CE-MS). Zebrane dane analityczne są analizowane za pomocą wielowymiarowych metod chemometrycznych oraz metod uczenia maszynowego. Ze względu na zdolność do wykrywania zmian w badanym materiale analitycznym powodowanych przez czynniki zarówno wewnętrzne jak i zewnętrzne, metabolomika wykazuje bardzo duży potencjał do wykorzystania w różnych gałęziach przemysłu, gdzie potrzebna jest powtarzalność procesów, dokładna analiza oraz autentykacja-uwierzytelnianie pochodzenia poszczególnych składników stosowanych w produkcji. Metabolomika może być stosowana w takich branżach przemysłowych jak przemysł spożywczy, biotechnologiczny, farmaceutyczny i kosmetyczny. Doskonale może sprawdzać się w medycynie do wyznaczania nowych celów terapeutycznych, pozwala na monitorowanie terapii oraz rozwoju stanów patologicznych. W toksykologii środowiskowej umożliwia określanie zmian w metabolomie organizmów po ekspozycji na dany stresor oraz zmiany środowiskowe. W opracowaniu przedstawiono przykłady aktualnych i potencjalnych zastosowań metabolomiki w różnych gałęziach przemysłu.

Abstract

Metabolomics, a field within omics sciences, is an analytical approach used to determine qualitative and quantitative changes in the composition of a sample (metabolome) using advanced analytical methods such as nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS) coupled with separation techniques (e.g., LC-MS, GC-MS, CE-MS). The collected analytical data are analyzed using multidimensional chemometric methods and machine learning techniques. Due to its ability to detect changes in the analyzed material caused by both internal and external factors, metabolomics has great potential for use in various industries where process repeatability, precise analysis, and authentication of the origin of individual components used in production are needed. Metabolomics can be applied in industries such as food, biotechnology, pharmaceuticals, and cosmetics. It can also be valuable in medicine for identifying new therapeutic targets, monitoring therapy, and the development of pathological conditions. In environmental toxicology, it enables the determination of changes in the organism’s metabolome after exposure to a specific stressor and environmental changes. This paper presents examples of current and potential applications of metabolomics in various industries.

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Bibliografia

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