Czasopismo | INŻYNIERIA MATERIAŁOWA | Rocznik 2011 - zeszyt 4

Surface functionalization for tissue analog of blood contacting materials

nr katalogowy: 62475

Blood contacting materials could initiate several processes, which can endanger the life, like the formation of thromboemboli. Properties of new designed materials could minimize influence of the human organism. For blood contact, the biocompatibility requirements are of the highest level of all biomaterial applications, which is due to the continuous blood flow and the high reactivity of blood molecules and cells. Blood contacting materials could initiate several life-endangering processes such as formation of thromboemboli, even in the presence of anti-clotting agents. Thus, our research in the frame of integrated national and international activity is focused on fabrication and diagnostics of materials characterized by reduction or erasing of thrombogenicity. In the last years of material development, lower thrombogenicity was primarily tried to reach by modifying existing material surfaces. Despite the successes in reducing protein and cellular deposits on some materials, this approach do not target to a truly non-thrombogenic surface. Recently, attempts are starting to create self-assembling layers. Such approach is realized in our research activity by the multidisciplinary, international work. Estimation of the cell-material interaction plays an important role in the biomaterial design. Titanium and carbon basis biomaterials, such as diamond-like carbon (DLC), titanium (Ti), and stoichiometric titanium nitride (TiN) as well as titanium carbo-nitrade (Ti(C, N)), seem to be good candidates for future blood-contact applications. These materials were deposited as thin films by the hybrid pulsed laser deposition (PLD) technique to examine the influence of such surfaces on cell behavior. The cell-material reactions were examined in static conditions and then subjected to a dynamical test by application of a radial flow chamber specially design to observe the cell detachment kinetics. Concept of design The concept of design is[...]

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e-Publikacja (format pdf) - nr 62475 "Surface functionalization..." licencja: Osobista Produkt cyfrowy	10.00 zł

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2011-4

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