Czasopismo | INŻYNIERIA MATERIAŁOWA | Rocznik 2010 - zeszyt 3

Numerical simulation of microstructure and internal stresses of the modified bone cement

nr katalogowy: 52780

Hip joint belongs to the most exploited carrying joints in the human motor organ [1]. Static and fatigue strengths affect the size of transferred stresses and overload capacity whereas the surface condition and its physical and chemical features determine the nature and the strength of joint at the border of bone-implant phases [2, 3]. Even though implantology gives possibilities of replacing damaged anatomical structures, it restores the lost functions only for a certain period of time. A reason of that is a wear and tear of artificial joints, which leads with time to a repeated failure of function [4÷7]. The bone cements are modified with many agents that improve their operational properties, with a modifying agent participating in polymerization reaction or being inactive. Addition of reactive modifying agents, apart from affecting strength properties, can also decrease the intensity of heat released during mixture hardening through extension of the reaction time or reduction of the amount of toxic MMA monomer being liberated into human organism after cement hardening [8, 9]. Gentamicin containing cements used so far show that within a certain time interval a drug is released from them into environment. Some authors are of the opinion that gentamicin release takes place by the diffusion of compounds through polymer matrix or capillary through the empty spaces inside it [10]. Nevertheless, a considerable part of scientists examining the phenomenon of drug release from bone cements think that it strongly depends on surface roughness [11÷13]. Until now, the phenomenon of gentamicin release has been closely examined. When comparing popular cements containing gentamicin used at present, one may conclude that release rate depends for the most part on such parameters as cement surface smoothness, porosity and wettability. These cements can be also modified with substances improving drug release rate [14]. Results of the abovementio[...]

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