Czasopismo | CHEMIK | Rocznik 2024 - zeszyt 1

Białko KRAS– struktura, aktywność i rola w terapiach przeciwnowotworowych

KRAS protein – structure, activity and role in anticancer therapies

10.15199/5.2024.1.4

nr katalogowy: 148527
10.15199/5.2024.1.4

Streszczenie

Białko KRAS w formie natywnej występuje w organizmie w formie aktywnej, wiążącej GTP lub nieaktywnej, wiążącej GDP. Formy te podlegają cyklicznym, ściśle regulowanym przemianom, dzięki czemu odgrywa ono kluczową rolę w regulacji szlaków sygnalizacyjnych związanych z proliferacją i przeżywalnością komórek. Jednakże białko to jest jednym z najczęściej mutujących onkogenów rodziny białek RAS, które prowadzą do jego niekontrolowanej nadaktywności, a poszczególne jego mutacje powiązane są z licznymi formami nowotworów, które jeszcze do niedawna traktowane były jako „nieuleczalne”

Abstract

The KRAS protein in its native form occurs in the body in anactive form - binding GTP and inactive-binding GDP. These forms are subject to cyclical, tightly regulated transformations, which play a crucial role in regulating signaling pathways related to cell proliferation and survival. However, this protein is one of the most frequently mutating oncogenes of the RAS protein family, which leads to its uncontrolled hyperactivity, and its mutations are associated with numerous forms of cancer that until recently were considered as “incurable”.

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Keywords

Bibliografia

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