Czasopismo | CHEMIK | Rocznik 2024 - zeszyt 1

Metody stabilizacji biokatalizatorów w syntezie organicznej

Methods of biocatalysts immobilization in organic synthesis

10.15199/4.2024.1.1

nr katalogowy: 148524
10.15199/4.2024.1.1

Streszczenie

Rozwój skutecznych metod stabilizacji enzymów jest kluczowy dla ewolucji i przemysłowego wdrażania procesów biokatalitycznych. Ciekawe podejście łączy proces stabilizacji białek w cieczach jonowych z immobilizacją fazy aktywnej na stałym nośniku. W efekcie otrzymuje się stabilne, aktywne i heterogeniczne biokatalizatory. Procesy heterogeniczne w produkcji niosą ze sobą wiele korzyści, jak np. łatwe oddzielenie biokatalizatora od mieszaniny reakcyjnej oraz możliwość recyklingu. W związku z tym przeprowadzono przegląd związany z wykorzystaniem materiałów typu supported ionic liquid phases jako skutecznych nośników w stabilizacji enzymów i ich zastosowaniu zarówno w procesach biokatalitycznych w systemie z przepływem ciągłym, jak i okresowym.

Abstract

Literature review, with 40 refs., of methods of enzyme immobilization in the reaction medium. Phys. (adsorption, trapping) and chem. (cross-linking, covalent bonding) enzyme immobilization techniques were discussed. The use of supported ionic liquid phase (SLIP) and supported ionic liquid-like phase (SILLP) as effective techniques for enzyme stabilization was presented. Examples of the use of immobilized enzymes on SILP and SILLP carriers in various chem. processes were presented

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Keywords

Bibliografia

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